Nutrition Guide

TRPP3, is a human protein encoded by the PKD2L2 gene. TRPP3 is a member of the transient receptor potential channel family of proteins.

TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.[1]

TRPML is a family of transient receptor potential ion channels. The three members of the TRPML sub-family are not well characterized. TRPML1 is known to be localized in late endosomes. This subunit also contains a lipase domain between its S1 and S2 segments. While the function of this domain is unknown it has been proposed that [...]

Cold-patches have traditionally been used to induce analgesia or relief in pain which is caused as result of traumatic injuries. The underlying mechanism of cold-induced analgesia remained obscure till the discovery of TRPM8. Three independent research groups have reported that mice lacking TRPM8 gene are severely impaired in their ability to detect cold temperatures.[4] Remarkably, these [...]

TRPM8 is an ion channel, upon activation it allows the entry of Na+ (sodium) and Ca2+ (calcium) ions to the cell that leads to depolarization and the generation of action potential. This eventually leads to the feeling of cold. The TRPM8 protein is expresed in sensory neurons, and it is activated by cold temperatures and cooling [...]

Transient receptor potential cation channel, subfamily M, member 8, also known as TRPM8, is a protein which in humans is encoded by the TRPM8 gene.

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name. TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both [...]

Transient receptor potential cation channel, subfamily M, member 5, also known as TRPM5, is a human gene encoding a protein of the same name.

Transient receptor potential cation channel, subfamily M, member 4, also known as TRPM4, is a human gene encoding a protein of the same name.

Transient receptor potential cation channel, subfamily M, member 3, also known as TRPM3, is a human gene. The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry [...]

Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a human gene. The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this [...]

Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential ion channel associated with focal segmental glomerulosclerosis.

Transient receptor potential cation channel, subfamily C, member 4, also known as TRPC4, is a human gene encoding a protein of the same name.

Transient receptor potential cation channel, subfamily M, member 1, also known as TRPM1, is a human gene. The protein encoded by this gene is similar to the transient receptor potential (Trp) calcium channel family members. The expression of this protein is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis[1]. The expression of the [...]

Among the functional responsibilities of the TRPM channels are: regulation of calcium oscillations after T cell activation (TRPM4).[6] sensory transduction in taste cells (TRPM5). regulation of magnesium reabsorption in the kidneys and absorption in the intestines (TRPM6).[7] regulation of cell adhesion (TRPM7).

The relative permeability of calcium and magnesium varies widely among TRPM channels. TRPM4/5 are impermeable to calcium. TRPM3/6/7 are highly permeable to both calcium and magnesium. The mechanism of activation also varies greatly among TRPM channels. TRPM2 is activated by ADP-ribose Adenosine 5′-diphosphoribose and functions as a sensor of redox status in cells.[3] TRPM4/5 are activated by intracellular calcium. TRPM8, conversely, [...]

TRPM is a family of transient receptor potential ion channels where the “M” stands for “melastatin”.[1] Functional TRPM channels are believed to form tetramers.[2] Unlike the TRPC and TRPV sub-families, TRPM subunits do not contain N-terminal ankyrin repeat motifs but, rather, contain entire functional proteins in their C-termini. TRPM6 and TRPM7, for example, contain functional ?-kinase [...]

Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a human gene encoding a protein of the same name.

Transient receptor potential cation channel, subfamily C, member 5, also known as TRPC5, is subtype of the TRPC family of mammalian transient receptor potential ion channels. Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin [1]. This activation probably plays a role in rheumatoid arthritis.

Transient receptor potential cation channel, subfamily C, member 4 associated protein, also known as TRPC4AP, is a human gene.